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老龄鼠

一、百奥动物老龄鼠优势


① 不同周龄小鼠现货提供;

② 高标准的饲养环境;

③ 非生产退役种鼠;

④ 严格的遗传稳定性监测。


二、C57BL/6J老龄鼠


C57BL/6J是使用最为广泛的近交品系之一,也是第一个完成基因组测序,特征分析最全面的小鼠品系。有研究人员对C57BL/6J的生存曲线进行分析,并提供了可比较的对应的人类年龄。衰老是个连续的动态过程,大多数研究将生命阶段简单的分为成年、中年和老年。


三、小鼠月龄和人类年龄对照关系及特点


① 小鼠的3-6月龄对应成年人(20-30岁);

发育完成尚未受到衰老影响。

② 小鼠的10-15月龄对应中年人(38-47岁);

可以检测到部分衰老生物标志物(非全部)的衰老变化。

③ 小鼠的18-24月龄对应老年人(56-69岁);

可以检测到几乎全部衰老标志物的衰老变化[1]


四、老龄鼠常见表型及病理


随着小鼠生长发育,外观会逐渐改变。一些常见的衰老表型有:眼周脱毛、嘴鼻部被理毛、背侧产生脱毛区及灰毛区等。


from clipboard

C57BL/6J老龄鼠的部分正常衰老表型[2]


同时随着年龄增长,与年龄相关的各项疾病也随之而来,产生一些和疾病相关的表型。例如:自发肿瘤、眼周病变、皮炎脱毛等。


非近亲繁殖小鼠长期研究(2年或更长时间)的常见疾病[3]

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a、Findings from multiple studies are summarized for each line or group. and original terminology.

b、4-way cross

c、(Af _ C57BL/6)F1

d、UM HET3 from (BALB/cByJ _ C57BL/6J)F1 _ (C3H/HeJ _ DBA/2J)F1 


五、老龄鼠应用研究


① 健康生命周期的基础生物学研究

② 骨质、肌肉、身体组成相关研究

③ 饮食、运动、认知与行为研究

④ 心血管、内分泌、代谢等疾病研究

⑤ 免疫学、肿瘤学、神经退行性疾病研究

⑥ 年龄相关的视力、听力障碍研究


六、参考文献



[1] Flurkey, K., M. Currer, J. & Harrison, D.E. Chapter 20 - Mouse Models in Aging Research. In: Fox, J.G. et al. (eds). The Mouse in Biomedical Research (Second Edition). Academic Press: Burlington pp 637-672(2007).

[2] https:// e. dxy. cn/ broadcast/ live/ id/ 22788/ ? source= wechat& sim= 1& sim_ token= jo3ALEk4m RZ9tfoghOHA rih1tV 6kp0IQvMAdhr7vws7ey9YqHi8uJxdmTk9vElaf

[3] C. F. Brayton, P. M. Treuting, and J. M. Ward.Pathobiology of Aging Mice and GEM: Background Strains and Experimental Design.Veterinary Pathology 49(1) 85-105(2012).