|Strain Name||SD-Ldlrtm1/Bcgen||Common Name||B-Ldlr KO rats|
|Aliases||FH, FHC, FHCL1, LDLCQ2|
The Low Density Lipoprotein (LDL) Receptor is a cell-surface receptor presented in clathrin-coated pits that mediates the endocytosis of LDL, the major cholesterol-carrying lipoprotein of plasma. Loss of Ldlr function leads to accumulation of excess LDL in the blood, leading to elevated serum cholesterol, especially when fed a high fat diet, which makes Ldlr knockout rat a good model for studying atherosclerosis. This rat can be used to support research in many areas including diabetes and obesity research, cardiovascular research, metabolism research etc.
Model validation and analysis