|
Common name |
B-hNECTIN4 MC38 | Catalog number | 310954 |
| Aliases | EDSS1, LNIR, PRR4, PVRL4, NECTIN4 | Disease | Colon carcinoma |
|
Organism |
Mouse |
Strain | C57BL/6 |
| Tissue types | Colon | Tissue | Colon |
Description
Tumor growth curve & Body weight changes
Subcutaneous homograft tumor growth of B-hNECTIN4 MC38 cells. B-hNECTIN4 MC38 cells (5x105) and wild-type MC38 cells (5x105) were subcutaneously implanted into C57BL/6 mice (female, 7-week-old, n=5). Tumor volume and body weight were measured twice a week. (A) Average tumor volume ± SEM. (B) Body weight (Mean± SEM). Volume was expressed in mm3 using the formula: V=0.5 X long diameter X short diameter2. As shown in panel A, B-hNECTIN4 MC38 cells were able to establish tumors in vivo and can be used for efficacy studies.
B-hNECTIN4 MC38 cells were subcutaneously transplanted into C57BL/6 mice (n=5). At the end of the experiment, tumor cells were harvested and assessed for human NECTIN4 expression by flow cytometry. As shown, human NECTIN4 was highly expressed on the surface of tumor cells. Therefore, B-hNECTIN4 MC38 cells can be used for in vivo efficacy studies of novel NECTIN4 therapeutics.
Subcutaneous homograft tumor growth of B-hNECTIN4 MC38 cells. B-hNECTIN4 MC38 cells (5x105, 1x106, 5x106) and wild-type MC38 cells (5x105) were subcutaneously implanted into B-hCD3E mice (female, 7-week-old). Tumor volume and body weight were measured twice a week. (A) Average tumor volume ± SEM. (B) Body weight (Mean± SEM). Volume was expressed in mm3 using the formula: V=0.5 X long diameter X short diameter2. As shown in panel A, B-hNECTIN4 MC38 cells were able to establish tumors in vivo and can be used for efficacy studies.
Subcutaneous homograft tumor growth of B-hNECTIN4 MC38 cells. B-hNECTIN4 MC38 cells and wild-type MC38 cells were subcutaneously implanted into B-h4-1BB mice (female, 7-week-old, n=6). Tumor volume and body weight were measured twice a week. (A) Average tumor volume. (B) Body weight. Volume was expressed in mm3 using the formula: V=0.5 X long diameter X short diameter2. As shown in panel A, B-hNECTIN4 MC38 cells were able to establish tumors in vivo and can be used for efficacy studies. Values are expressed as mean ± SEM.
