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RenNano: Fully Human Nanobody Mice Platform

Fully human heavy chain variable region and modified constant region

Robust immune response compared with RenMab mouse

Diversity of the antigen-specific antibodies discovered from RenNano

High binding affinity at nanomolar range

Good developability


AACR 2023: RenNano® Mice: A Heavy-Chain-Only Antibody Platform for the Generation of Nanobody Therapeutics

AACR 2023: Discovery of RenNano®-Derived Human Heavy-Chain-Only Antibodies That Cross the Blood-Brain-Barrier