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B-Rank-iCre mice
Strain Name


C57BL/6-Ranktm1(icre)Bcgen/Bcgen


Stock No. 

110133

Common name


B-Rank-iCre mice


Gene symbol and name 

Tnfrsf11a, tumor necrosis factor receptor superfamily, member 11a

Strain of origin

C57BL/6

Chromosome  1
Coat color Black Dietary information

Growth and reproduction diet for experimental mice

Results of agarose gel electrophoresis

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Gel image of PCR products. PCR products are separated by gel electrophoresis on a 2% agarose gel. PC: samples used for PCR were collected from heterozygous mice; WT: samples used for PCR were collected from wild type mice; H2O: blank control.


Phenotype Analysis



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Scheme for generating Wnt7bRANK mice. Rosa26-Wnt7b mice were generated and crossed with RANK-Cre mice (RANK-Cre was purchased from Biocytogen Co. Ltd., Beijing, China) to obtain Wnt7bRANK mice. Wnt7bRANK mice similar to the overexpression of Wnt7b in osteoblasts. the three-dimensional reconstruction of mCT scanning showed a significant increase in bone mass in both trabecular and cortical bone in Wnt7bRANK mice compared to their littermates (Rosa26Wnt7b,hereafter referred to as wildtype or WT).

(source: Wu F et al., 2021)