Immunodeficient (B-NDG) mice_Biocytogen Pharmaceuticals (Beijing) Co., Ltd._Biocytogen, drug development, antibody discovery

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Immunodeficient (B-NDG) mice

Product No	Product	Application area
110586	B-NDG mice	Immune reconstitution, CDX, transplantation, drug evaluation
110586	B-NDG mice-PDX	Immune reconstitution, CDX, transplantation, drug evaluation
110587	B-NDG nude mice	Human immune system reconstitution
110601	B-NDG B2m KO mice plus	Reduce PBMC reconstitution GVHD response and prolong experimental window
110600	B-NDG hIL15 mice	Promote human NK cell differentiation
110599	B-NDG HLA-A2.1 mice	Vaccine study
110596	B-NDG hIL6 mice	Promotes human monocyte differentiation
110590	B-NDG hTHPO mice	Without irradiation, it reduces the damage caused by irradiation to mice
110604	B-NDG hSIRPA mice	Maintain progenitor capacity
120612	B-NDG hIL7/hIL15 mice	Promote differentiation of human T cells and NK cells
110603	B-NDG hSIRPA/hCD47 mice	Evaluation of pharmacodynamic and toxicity of CD47, SIRPA targeted drugs
120609	B-NDG hCSF1/hTHPO mice	Promote differentiation of human myeloid cells without irradiation
112874	B-NDG hB2M/HLA-A24.2 mice plus
112873	B-NDG hB2M/HLA-A3.1 mice plus
112774	B-NDG hALB/hFcRn mice
112864	huHSC-B-NDG hIL6 mice	Promote differentiation of human monocyte-macrophage
112480	huHSC-B-NDG hTHPO mice	Irradiation is not required to avoid damage to mice caused by irradiation
112479	huHSC-B-NDG MGMT3 mice	Promote differentiation of human myeloid cells；Irradiation is not required to avoid damage to mice caused by irradiation
112865	huHSC-B-NDG HLA-A2.1 mice	To verify the efficacy of HLA-A2.1 restricted vaccines；Promote the development of human CD8+ T cells
112451	B-NDG hB2M/HLA-A11.1 mice	To verify the efficacy of HLA-A11.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
112560	B-NDG hB2M/HLA-A24.2 mice	To verify the efficacy of HLA-A24.2 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
112450	B-NDG hB2M/HLA-A3.1 mice	To verify the efficacy of HLA-A3.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
112256	B-NDG H2-K1/H2-D1 KO mice	No MHC class I molecule expression; Reduce GVHD and prolong the experimental window period; Improve the accuracy of efficacy verification
111982	B-NDG hALB mice	Used for pharmacological or pharmacokinetic studies of drugs that utilize albumin to extend their half-life
112653	B-NDG hIL15, FcγR KO mice	Promote differentiation of human NK cells；No mouse Fc receptor function
112478	huHSC-B-NDG hIL15 mice	Promote differentiation of human NK cells
112482	huNK-B-NDG hIL15 mice	Promote differentiation of human NK cells
112449	B-NDG hB2M/HLA-A2.1 mice plus	To verify the efficacy of HLA-A2.1 restricted vaccines and antibody-based therapies；Promote the development of human CD8+ T cells
112470	huHSC-B-NDG mice	Human immune system reconstitution, mainly T cells and B cells；reconstitutionl Human-derived cell or tissue engraftmentl Tumor research；Human disease model studyl Efficacy and toxicity verification for
112469	huPBMC-B-NDG mice	Human T cell reconstitution；Human-derived cell or tissue engraftment；Tumor researchl Human disease model study；Efficacy and toxicity verification for human targeted drugs
110593	B-NDG hGM-CSF mice	Promote differentiation of human myeloid cells；For mating with other humanized mice that promote myeloid cell differentiation to obtain multi-humanized mice
110598	B-NDG hairless mice	Hairless, easy to measure tumor
110597	B-NDG hIL7 mice	Promote differentiation of human lymphoid cells
110595	B-NDG H2-Ab1 KO mice	No MHC class II molecule expression; Reduce GVHD and prolong the experimental window period；Improve the accuracy of efficacy verification
111882	B-NDG MGMT3 mice	Promote differentiation of human myeloid cells；Irradiation is not required to avoid damage to mice caused by irradiatio
111895	B-NDG MHC I/II DKO mice plus	No MHC class I/II molecule expression；Reduce GVHD and prolong the experimental window period；Improve the accuracy of efficacy verification
111922	B-NDG hFcRn mice	PK (NDG background can reduce ADA)
111856	B-NDG B2m plus/hIL15 mice	Human immune system reconstitution
110605	B-NDG Hc mice	Antibody CDC function study

Biocytogen is headquartered in Beijing, with branches in Haimen, Jiangsu, Boston, Shanghai. Its wholly-owned subsidiary, Eucure Biopharma, focuses on clinical development.